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KMID : 0366220110460030180
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Korean Journal of Hematology
2011 Volume.46 No. 3 p.180 ~ p.185
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Fludarabine-containing chemotherapy for patients with previously untreated low-grade non-Hodgkin’s lymphoma
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Ahn Jae-Sook
Yang Deok-Hwan
Jung Sung-Hoon
Thanh Tran Huong Thi
Park Hyung-Chul
Kim Ha-Na
Kim Yeo-Kyeoung
Kim Hyeoung-Joon
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Abstract
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Background: The clinical efficacy and safety of fludarabine combination chemotherapy was investigated for the treatment of previously untreated patients with low-grade (NHL).
Methods: Twenty-five patients who were newly diagnosed as low-grade NHL were treated with fludarabine combination chemotherapy. Fludarabine combination regimens consisted of fludarabine, mitoxantrone and dexamethasone or fludarabine, cyclophosphamide and mitoxantrone with or without rituximab and repeated every 4 weeks.
Results: The median age was 60 years (range, 35-77 years), with 13 of 25 patients (52%) ≥60 years of age. Seven of 25 patients (28%) with an intermediate risk follicular lymphoma international prognostic index (FLIPI) and 9 of 25 patients (36%) with a high risk FLIPI were enrolled in this study. The delivered median number of chemotherapy was six (range, 2-9 cycles). The overall response rate with fludarabine-based treatment was 88%, including 52% complete remission and 36% partial remission. During the median follow-up of 19 months, the estimated 2-year event-free survival was 63±10% (95% CI, 43-83) and the 2-year overall survival was 78±9% (95% CI, 60-96). Fludarabine combination chemotherapy was frequently associated with grade 3 or 4 neutropenia in 84% patients. However, neutropenic infection was observed in only one (4%) patient. Four patients (16%) showed grade 3 or more non-hematologic toxicities, such as acute coronary syndrome, intracranial hemorrhage, anaphylaxis and gastric cancer.
Conslusion: Fludarabine-combination treatment was a highly active regimen with well toleration in untreated low-grade NHL.
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KEYWORD
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Fludarabine, Primary, Lymphoma
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